Not a dumb question all.
I have my macros at the 3, 5 and 6 keys. This is because I can easily reach 1, 2, 3, and 4 with my left hand and still hit ctrl, alt, or shift if I need to. Generally, I keep 1 for a hard cast of a mob grab (like Death Grip, Throw Glaive, Leap of Faith). 2 is almost always a movement ability. 3 is always the main macro I might use, so, in this case, the DPS macro. 4 is my other movement ability if I have one, or taunt for my tanks.
I use a Razer keyboard and 3, 5, and 6 are also set to repeat when in-game. I also have a row of custom keys near WASD so I put 3, 5, and 6 over there so they are still in reach.
So I’ll move with WASD, cast with the above keys, and mouselook (and sometimes mouse move depending on what keys I’m holding). Everything stays within reach of my left hand.