Help with macro usage

Ok guys first let me say Thank you for such an awesome program it has given me the ability to play the game again. My question is simply, some of these macros call for pressing the CTRL, SHIFT, or ALT keys. I am unable to use these modifier keys because of my disability. I set my macro for thumb buttons on my mouse. Is there any way someone can first explain to me how I am supposed to use the macro with the modifier key and also how can I remove the need for a modifier key in the macro or will it break the macro??