mouse clicking

Just curious i have heard some people talking about they are setting there mice to .250 spd ect and like a program and so on. Is this a mouse that auto clicks at that spd and a program that does it for your keyboard? Is that what you need to make sure these macros work at their best potential?

There are some programs that let you adjust the clicking speed. I use the autohotkey program. There are also keyboards and a mice that you can control the clicking speed. I think the Razor brand is the most popular one.